“amount of RNA G-quadruplexes (rG4s) in hippocampal tissue increases as a function of age, and what’s more, it increases as a function of the severity of diagnosed Alzheimer’s at the time of death”

https://www.science.org/content/blog-post/neurodegeneration-might-come-down-rna

I have long thought Alzheimer’s is basically accelerated brain aging. If we live long enough we all get disabled.

“rG4 staining is also strongly influenced by the APOE4 status of the individuals”

End of outdoor ice rinks in Minneapolis makes it to WaPo.

https://www.washingtonpost.com/nation/2025/02/24/climate-change-ice-rinks-minnesota/

This has been happening for years across the MSP region and across Canada. Our cross-country ski trails are likewise doomed (making snow for XC skiing is … wrong. I understand. I grieve. But it’s dead. Let it go.)

Without outdoor ice Hockey will also slowly fade.

Even though it’s old news, I’m glad to see mention of it.

Rubio tells EU: “ignore the boss, we really aren’t doing what he says we are doing”

https://www.nytimes.com/2025/02/20/us/politics/rubio-russia-europe.html

Nobody believes him.

Also, this was atypically good NYT reporting:
“[Trump] ….mocked Ukrainians’ complaints that their country, having sacrificed tens of thousands of lives to preserve its independence, had been left out of negotiations about its future”

GLP-1 and visual problems: “GLP-1 drugs might be causing at least some of these cases indirectly, by rapidly lowering blood sugar, rather than through any direct toxic effect of the medication itself”

https://gizmodo.com/eye-doctors-are-finding-new-links-between-ozempic-and-vision-problems-2000563080

A friend of mine developed a kind of persistent neuropathy/myopathy after rapidly lowering their “type II” glucose levels — but not by a GLP-1.

There’s a lot about “Type II” DM we don’t understand, including the shifting balance between insulin resistance and beta cell failure.

Apple introduces ability to migrate all purchases from one account to another account

https://support.apple.com/en-us/117267

We have a family Apple ID that exists only because it owns so many purchases. I advise WAITING a few months before trying this. There are likely surprises.

If we do it we’ll be able to enlarge our family sharing; the legacy Apple ID is a family member.

“If there’s anything else associated with your secondary Apple Account that you still need access to, you might need to undo migration. iCloud data from your secondary account can still be easily accessed by signing in to iCloud.com on a computer.”

“nearly one of every four workers is functionally unemployed in America today”

https://www.politico.com/news/magazine/2025/02/11/democrats-tricked-strong-economy-00203464

The data is not bad, but our framing of the data is weirdly rigid. The price for failing to dig into the state of America over the past 25y is we got Trump.

“since 2001, the cost of living for Americans with modest incomes has risen 35 percent faster than the CPI”