“chances of finding a de novo mutation go up if a patient has severe autism and other, co-occurring conditions, like epilepsy, movement disorders or an intellectual disability. “

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https://www.seattletimes.com/nation-world/a-furious-debate-over-autisms-causes-leaves-parents-grasping-for-answers/

De novo mutations are mistakes during routine DNA manipulation, not inherited. Autism is a crap syndromic term for a wide range of conditions many of which are associated with a variety of inherited and de novo mutations in a wide variety of proteins. There really doesn’t seem to be a single cause to focus on.