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Monthly Archives: March 2022

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Frontotemporal Dementia: “we may end up classifying aggregation diseases as much by their protein folds as by the names of the individual proteins involved”

Posted on March 31, 2022 by jgordon

Link. Damn. Progress. PS Does HCQ changes lysosomal pH?

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Evolution of the mammalian brain.

Posted on March 31, 2022 by jgordon

Link. As predicted but great to see the evidence.

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Mulvaney of CBS.

Posted on March 31, 2022 by jgordon

Link. A milestone in the long decay of broadcast television.

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What is triald and why is it taking so much disk space? (Big Sur+)

Posted on March 31, 2022 by jgordon

Link. “Trial’s root directory at ~/Library/Trial should be added routinely to all backup exclusion lists. Apple should add it to Time Machine’s system exclusions at the earliest opportunity.”

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“ U.S. Marines may have seen the writing on the wall; this year they will stop using tanks.”

Posted on March 31, 2022 by jgordon

Link. Javelins.

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ALS experimental treatment “25 percent slower decline for patients receiving the treatment.” but no longevity and no change in objective measures.

Posted on March 31, 2022 by jgordon

Link. I doubt it works.

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Episodic exhaustion responding to migraine therapy.

Posted on March 31, 2022 by jgordon

Link. That is a really weird case. Patient had migraines but they morphed in an extreme way.

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China: “departure from the heavy silence that has prevailed under Mr. Xi’s rule”

Posted on March 31, 2022 by jgordon

Link. Watching this space.

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“if you are boosted and have already had Omicron, you probably don’t need another booster yet”

Posted on March 31, 2022 by jgordon

Link. Why I’m waiting until Aug/Sept.

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Why … “fears about sexual orientation and trans rights be so powerfully motivating that it could help convince people to sacrifice fundamental political rights?”

Posted on March 31, 2022 by jgordon

Link. Great question.

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Why … “fears about sexual orientation and trans rights be so powerfully motivating that it could help convince people to sacrifice fundamental political rights?”

Posted on March 31, 2022 by jgordon

Link. Great question.

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“Ginni Thomas was a guiding force for Groundswell, setting agendas for its meetings and actively coordinating messaging among its participants, and that the group had a dark, paranoid, and Manichean view of American politics.”

Posted on March 31, 2022 by jgordon

Link. Bonkers for years.

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“Western analysts took basic metrics (such as numbers and types of tanks and aircraft), imagined those measured forces executing Russian military doctrine, then concluded that the Ukrainians had no chance.”

Posted on March 31, 2022 by jgordon

Link. The war is in its early days however.

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“Surely Putin would be satisfied by the annexation of Crimea”

Posted on March 31, 2022 by jgordon

Link. Germany especially should have worried more. “So are Belarus, North Korea, Venezuela, Iran, Nicaragua, Hungary”. And probably Saudi Arabia. Israel?

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For mental health “moderate exercise may be the most beneficial for mental health”

Posted on March 30, 2022 by jgordon

Link. She’s a hard core athlete but her research favors moderate exercise. Interesting focus on neuroinflammation in treatment resistant depression.

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“Mr. Putin seemed genuinely unaware that the Russian military had been using conscripts in Ukraine, and that drafted soldiers were among those killed in action.”

Posted on March 30, 2022 by jgordon

Link. That’s very precise Intel. Not much surprises me any more, but this is amazing.

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“a point of light lined up with one of the ripples, and its shine was magnified by a thousandfold or more.” Ripples in space-time.

Posted on March 30, 2022 by jgordon

Link. Star 900 million years after the Big Bang. Long long dead “now”.

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Oliver Sacks’ Days on Muscle Beach

Posted on March 30, 2022 by jgordon

Link. “with the speed of reflex I grabbed our patient and held him upside down; his cerebellar tonsils and brain stem went back into the skull, and I felt I had snatched him from the very jaws of death.”

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Apple only pushes iOS auto-updates after collecting early adopter experience.

Posted on March 30, 2022 by jgordon

Link. Manual updaters are doing release testing. This is what I thought Apple did and it’s great.

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“Cruz and John Eastman, the author of the Eastman memo outlining a strategy for then–vice president Mike Pence to throw the election to Trump, have been friends for close to 30 years, since they clerked together for then–U.S. Appeals Court judge J.

Posted on March 30, 2022 by jgordon

Link.

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“3.39-fold higher risk of genital defects in these children [of fathers taking metformin] compared to others”

Posted on March 29, 2022 by jgordon

Link. Also seen in some animal studies so more likely real. This is terrible news. What is the mechanism?!

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Russian oligarchs used Britain’s insane libel law to silence the truth and keep power.

Posted on March 29, 2022 by jgordon

Link. The libel laws must be reformed. Also, England is deeply compromised.

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Remembering Grozny.

Posted on March 29, 2022 by jgordon

Link. Putin’s next step is to amplify the war crimes and kill everything.

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“hypothesis that present-day Pluto is an ocean world”

Posted on March 29, 2022 by jgordon

Link. “Signs of cryovolcanic activity on the dwarf planet in the recent geological past must be driven by an underground body of water”

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CivTech: So you want to reform democracy (2015)

Posted on March 29, 2022 by jgordon

Link. Written before the Trump crisis. Still a good guide.

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“Apple reports that running face recognition end-to-end on a recent ANE takes less than 4 ms, which is eight times faster than running it on a GPU.”

Posted on March 29, 2022 by jgordon

Link. All local.

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Spacecraft Debris Odds Ratio.

Posted on March 29, 2022 by jgordon

Link. This should be part of medical student education.

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Eastman: “Election was Stolen by a strategic Democrat plan to systematically flout existing election laws for partisan advantage; we’re no longer playing by Queensbury Rules.”

Posted on March 29, 2022 by jgordon

Link. A classic bit of delusion, self-justification, and faux-tough rhetoric

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“the federal judiciary is now heavily weighted toward judges with backgrounds representing the rich and powerful”

Posted on March 28, 2022 by jgordon

Link. Good backgrounder. Jackson also served wealth, but not ONLY wealth. “Biden himself briefly worked as a public defender”

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Scout early warning system for near-earth asteroid strikes.

Posted on March 28, 2022 by jgordon

Link. “a city faced with a future Chelyabinsk-like space rock can at least be warned”. Taking shelter would avoid injuries.

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The CalDigit TS4 and OWC T4 Docks

Posted on March 28, 2022 by jgordon

Link. About $380. He mentions T4 cable he likes.

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Museum docent volunteers: “older, white females for an art museum, or older white men for a railway museum”

Posted on March 27, 2022 by jgordon

Link. Since this 2019 article many are ending volunteer programs and creating employee roles instead. The goal is to be less white/more diverse.

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African COVID: mystery or hidden mortality?

Posted on March 27, 2022 by jgordon

Link. Probably some of both. Little interest in vaccine.

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“it’s easier to encode instructions for building simple, symmetrical structures”

Posted on March 27, 2022 by jgordon

Link. Why natural selection favors symmetry.

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“several energy companies have held ownership stakes in the power plant, major corporations with interests far beyond West Virginia.”

Posted on March 27, 2022 by jgordon

Link. Manchin’s corruption is out in the open.

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“The argument for a return to prepandemic norms is straightforward”

Posted on March 27, 2022 by jgordon

Link. Deglobalization would drive a reindustrialization of America. There would be places for money to go.

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Kyiv and Kabul: One fought, one not.

Posted on March 27, 2022 by jgordon

Link. Both times US guessed wrong.

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“It’s fun to sit at the guillotine and watch these people that you resent getting their heads chopped off. There were wild street dances.”

Posted on March 27, 2022 by jgordon

Link. Usually an “elite”; someone the dancers secretly believe is better than them.

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“the U.S. Treasury made $28 billion in special payments, known as “Trump bribes,” in my hometown, to compensate U.S. farmers for phantom losses due to Chinese perfidy.”

Posted on March 27, 2022 by jgordon

Link. Vote buying essentially.

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“Ms. Rice was similarly struck. “Something is definitely different,” she said. “He’s not in control of his emotions. Something is wrong.”

Posted on March 27, 2022 by jgordon

Link. Portrays Putin as getting progressively nastier and more corrupt over 20y. Feels inevitable.

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“Russia used to be much colder and much more northern country with its most productive, advanced and richest population living far north. In fact, just 350 years ago pretty much all of Russian taxpayers used to live in the towns of Arctic region.”

Posted on March 26, 2022 by jgordon

Link.

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“New research supports doctors’ earlier theories that girls who developed tics during the pandemic had pre-existing mental-health issues making them susceptible to other disorders.”

Posted on March 26, 2022 by jgordon

Link. TikTok Tourettes.

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Events Calendar (events calendar.co)

Posted on March 26, 2022 by jgordon

Link. It’s $5/month to do anything interesting but I’m considering it for my bike outings.

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Bike MN events calendar

Posted on March 26, 2022 by jgordon

Link. Bike related events across MN. Only a fraction of what’s happening but a good place to check when every quarter or so.

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“Apple silently provided an option to bring back proxy icons completely in macOS 12 Monterey.”

Posted on March 26, 2022 by jgordon

Link. Apple hides a lot of these quiet retractions in Accessibility. Adam has great examples of how to use the proxy icon.

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Willam Barr: “Rather, he said, they meant individual morality: the ability to govern oneself. And, since people are inherently wicked, that self-government requires the authority of a religion: Christianity.”

Posted on March 26, 2022 by jgordon

Link. “Madison never actually said the quotation on which Barr based his argument.”

WTF do I only read this now? Why is HCR the only source?

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“Mr. Browder’s relentless lobbying over the next decade—driven by grief and anger over Magnitsky’s murder”

Posted on March 26, 2022 by jgordon

Link. Putin has many enemies.

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Franklin Graham: “A few days before the invasion of Ukraine, he asked people to “pray for Putin”

Posted on March 26, 2022 by jgordon

Link. Evangelicals.

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“In the 1950s, the Supreme Court based civil rights decisions on the Fourteenth Amendment, and it continued that trajectory in the 1960s and 1970s.”

Posted on March 25, 2022 by jgordon

Link. Today’s GOP hates the 14th.

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Cancel Culture defined.

Posted on March 25, 2022 by jgordon

Link. Is real. Zealotry a core component, forgiveness forbidden.

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