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Trastuzumab deruxtecan effective in low HER-2 metastatic breast cancer.

Posted on June 7, 2022 by jgordon

Link. Two years more. Progress.

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“a user can set up an account recovery contact to make sure that they always have access to their account, even if they forget their Apple ID password or device passcode.”

Posted on June 7, 2022 by jgordon

Link. Can I back them up myself?

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“Longer torso and long arms = poor deadlift”

Posted on June 7, 2022 by jgordon

Link. Why I should NOT lift from the floor.

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“private-equity firms and developers are often circling nearby, looking to buy up such properties and turn them into more lucrative ventures”

Posted on June 7, 2022 by jgordon

Link. 20 million Americans in mobile homes facing real trouble.

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Global markets, photolithography: “The world market … dominated by a single firm in the Netherlands, ASML:

Posted on June 7, 2022 by jgordon

Link. A good example.

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Crypto: “It sounds extreme and implausible to suggest that an asset class that has become so large, whose promoters have acquired so much political influence, could lack any real value.”

Posted on June 7, 2022 by jgordon

Link. K discounts the illegal too quickly.

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Gun cult: “Americans are actually far more religious than adults in other wealthy nations, so we are not suffering from a prayer deficit.”

Posted on June 7, 2022 by jgordon

Link. Clearly we need to promote atheism.

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Fox: “News Media CEO Suzanne Scott decided to lure viewers back by giving them, as he notes, what they wanted: “False hope.”

Posted on June 7, 2022 by jgordon

Link. Fox went insane because their audience is insane.

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Hacking Bitcoin: “the extranonce’s leaky behavior was tolerated because it allowed Bitcoin’s creator to keep an eye on miners”

Posted on June 7, 2022 by jgordon

Link. “even on occasions when the mining pool became centralized, the dominant miners declined to attack it.”

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“Google Wave would go on to revolutionize how we call, communicate, work, and interact online. It remains an indispensable tool to this day, but could its runaway success story…”

Posted on June 6, 2022 by jgordon

Link. A startling into to Apple Freeform.

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New parental controls come to iOS 16.

Posted on June 6, 2022 by jgordon

Link. It’s been a dumpster fire in an earthquake.

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The end of SETI@home.

Posted on June 5, 2022 by jgordon

Link. I ran it for a time.

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12 of Google failures.

Posted on June 5, 2022 by jgordon

Link. Taught me to never trust Google.

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“the speech was bland. Its long sentences were hard to follow. It was vague”

Posted on June 5, 2022 by jgordon

Link. Marshall presents his plan for Europe.

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Longevity and coffee: “the study didn’t find the same correlation for artificially sweetened coffee.”

Posted on June 5, 2022 by jgordon

Link. Wealthier people buy quality coffee and drink it without sweetener.

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“The first thing that motivated New Industrialism was the China Shock.”

Posted on June 5, 2022 by jgordon

Link. “our economy had become too financialized”. Now if only the GOP would go away…

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Early use of checkpoint inhibitor with 100% remission in 18 patients with rectal cancer.

Posted on June 5, 2022 by jgordon

Link. The inhibitors can help when all else fails, but this is about using them first. We’ve not done that. With this kind of result there may be immediate off-label use.

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“Cupertino plans to dis-intermediate the mobile carriers — becoming themselves a satellite-based global phone and data company.”

Posted on June 4, 2022 by jgordon

Link. That would be interesting.

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The 10,000 Swing Kettlebell Workout

Posted on June 4, 2022 by jgordon

Link. In comments a then 70yo cut the reps in half. That sounds right for 70. I’d do women’s weight.. Doesn’t need a lot of equipment.

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“Fuelled by international private equity funds, consolidating firms have been on a tear in other health-professional fields as well, buying up practices in fields such as veterinary medicine, dental care, optometry and pharmacies and assembling them int

Posted on June 4, 2022 by jgordon

Link. PE is a parasite.

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“At another black site in 2004, the C.I.A. infused a dietary supplement into his rectum for refusing to eat.”

Posted on June 3, 2022 by jgordon

Link. The Bush-Cheney-Haspel torture program. America never recovered, never will.

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WorldWideWeb: a simple web server for iPadOS and macOS.

Posted on June 3, 2022 by jgordon

Link. Free.

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SoftBank Vision fund: “for many of its portfolio companies to earn their first profit, or to sustain those they were beginning to enjoy, they’d need more than cash to burn—they’d need to restructure society to realize profits that were previously

Posted on June 3, 2022 by jgordon

Link.

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WWDC 2022 Wish List – Tsai Compilation.

Posted on June 3, 2022 by jgordon

Link. Like Thai I wish Apple would just fix bugs.

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“stupid may be one of Washington’s last taboos”

Posted on June 3, 2022 by jgordon

Link. Lots of rich and powerful are dim. You can call them ugly or mean or fat but “dim” really stings.

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“Ignore what they are thinking of you because they are not thinking of you.”

Posted on June 3, 2022 by jgordon

Link. Mostly true “life hacks”. I’ve read the originals as well.

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“difference between the poll findings and the gun referendum results is especially large. It is an order of magnitude larger than on other issues”

Posted on June 3, 2022 by jgordon

Link. Polls are cute but votes are what matter. The American gun cult is sustained by the American voter.

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“most liver cells replace themselves about once a year, and on average, our liver stays under the age of three.”

Posted on June 2, 2022 by jgordon

Link. Underappreciated organ.

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“there was an assassination attempt on Putin’s life in March”

Posted on June 2, 2022 by jgordon

Link. Also the cancer.

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“Tanuja Gupta, a senior manager at Google News who invited Soundararajan to speak, resigned over the incident,”

Posted on June 2, 2022 by jgordon

Link. Pichai is Brahmin.

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Which are more reliable: hard disks or SSDs?

Posted on June 2, 2022 by jgordon

Link. Some of my backup drives are over 8yo. Retired because capacity too small.

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“Chlorthalidone is more potent than Hctz (lowers SBP 10 mmHg more). Hctz immediate release only covers daytime hypertension.”

Posted on June 1, 2022 by jgordon

Link. Not widely understood.

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“Nearly 40 percent of full-time undergraduates who enrolled in the 2011-12 academic year accumulated some debt but did not have a degree after six years”

Posted on June 1, 2022 by jgordon

Link. We have more than one debt and education problem.

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“As local news media has disappeared “pink slime” outlets like LGIS have taken their place”

Posted on June 1, 2022 by jgordon

Link. The death of local journalism is a legitimate national security issue. “… Brian Timpone, a conservative businessman and former journalist with a record of plagiarism and fabrication.”

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Computing with a vibrating titanium plate neural network.

Posted on May 31, 2022 by jgordon

Link. Back to analog. Reminds me of ‘principle of least effort’ in physics.

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HP Cray EX: “Frontier uses more than 9,400 AMD-powered nodes and requires over 90 miles of networking cables. Around 6,000 gallons of water flow through the system every minute, ORNL says.”

Posted on May 31, 2022 by jgordon

Link. Won’t be a phone in 2050.

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Musk: “an avenger in the Tucker Carlson cinematic universe, alongside Kyle Rittenhouse, JD Vance, and the MyPillow guy”

Posted on May 31, 2022 by jgordon

Link. A is for asshole.

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Bicycles and Bicycling by the NYT

Posted on May 30, 2022 by jgordon

Link. The NYT has topical guides – including bicycling. Somehow I did not know this. Lots from their May 23 Summer of Cycling issue. (The TIMES TOPICS link is broken.)

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FIDO (passkey) standard doesn’t support switching identify vendor.

Posted on May 30, 2022 by jgordon

Link. The bigger issue is using passkey isn’t practical with multiple identity vendors. You have to pick just one and not mix them — or you’ll never remember which to use when

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Putin’s rumored illnesses: a summary.

Posted on May 30, 2022 by jgordon

Link. I wonder if more than one.

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Fixing Japan’s productivity failures: more capitalism.

Posted on May 30, 2022 by jgordon

Link. They are in an interesting trap.

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Antigen testing: “20 percent were still positive on Day 11”

Posted on May 29, 2022 by jgordon

Link. If you are well stop testing and do your isolation interval.

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“How long are Americans sad and angry about mass shootings? Four days.”

Posted on May 29, 2022 by jgordon

Link. Sounds right.

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“Rupert Murdoch, for translating the El Paso, Buffalo, and Pittsburgh shooters’ screeds into prime-time programming.”

Posted on May 29, 2022 by jgordon

Link. The enablers. Fox money comes from cable. Cut the cable.

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“quantum mechanics predicts that Hyperion’s chaotic motion shouldn’t last longer than about 20 years. But it has lasted much longer. So, quantum mechanics has been falsified.”

Posted on May 28, 2022 by jgordon

Link. “Systems with linear equations like this don’t have chaos. To have chaos you need non-linear equations.” Schrödinger WE is linear.

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GOP gun control. In Florida.

Posted on May 28, 2022 by jgordon

Link. Required full Dem support, committed GOP governor, some GOP support. Cratered gov NRA rating but there was NO political cost.

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“incident commander believed more equipment and people were needed for a “breach,”

Posted on May 28, 2022 by jgordon

Link. I’m glad I’m not that person.

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Bypassing US COVID travel rules by lying on Canadian entry forms.

Posted on May 28, 2022 by jgordon

Link. The article should be more clear this requires lying on the Canadian entry form. Penalty up to 6m in prison, 750k fine.

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“Stegosaurus and Triceratops actually reduced their metabolisms over time, ending up at metabolic rates closer to those of modern reptiles.”

Posted on May 28, 2022 by jgordon

Link. Hot blood is expensive.

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“Apple released its favourite algorithm, known as Lempel-Ziv Finite State Entropy or LZFSE, as open source in 2015”

Posted on May 28, 2022 by jgordon

Link. Brief readable summary of lossless compression. It was such a mess in the 80s. Lots of patent issues.

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